August 7, 2024 from DATAC
Research presented at the American Heart Association Basic Cardiovascular Sciences Scientific Sessions 2024 examined the complex relationship between alcohol consumption and heart health. The two studies, conducted on rodents, provide new insights into the risks of binge drinking and how alcohol impacts cardiovascular function, especially among women.
Alcohol and Arrhythmia: Binge Drinking’s Hidden Dangers
The first study, led by researchers from the Ohio State University College of Medicine, focused on the link between binge drinking and the development of atrial fibrillation (AFib)—a type of irregular heartbeat. According to Dr. Saugat Khanal, the lead author, “Our study in mice explored the mechanism of alcohol-induced arrhythmia and a possible way to prevent it in the future.”
The research showed that over 70% of mice exposed to binge drinking developed AFib. The study also identified a key stress-induced protein called JNK2, which plays a significant role in triggering these arrhythmias. Interestingly, mice that were given Alda-1, a cardiac protective agent, did not develop AFib.
While abstinence from alcohol can prevent most AFib risks, Dr. Khanal expressed concern that binge drinking remains common. “Our findings suggest that developing new drugs, including Alda-1 and other JNK2-specific inhibitors, may be an effective anti-AFib strategy for people with holiday heart syndrome,” he noted.
Alcohol, Estrogen, and Heart Function: Unique Risks for Women
The second study, conducted by a team from the Brody School of Medicine at East Carolina University, focused on how alcohol affects heart function in menopausal women receiving estrogen replacement therapy. Prior studies have indicated that alcohol has a more negative impact on cardiovascular health in women compared to men. This study aimed to explore the interplay between estrogen levels and alcohol exposure.
The researchers found that menopausal rats exposed to both alcohol and estrogen replacement therapy experienced mixed effects. On the positive side, they showed lower weight gain and fat mass, but on the downside, these animals exhibited higher blood pressure and increased heart rate.
“It was surprising to see the significant impact estrogen had on alcohol-induced heart dysfunction, despite its known cardioprotective effects,” said Dr. Syed Anees Ahmed, the study’s lead author. He cautioned that women using hormone replacement therapy should carefully consider their alcohol consumption, as it could pose risks to their cardiovascular health.
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